WebThe beta-lactamase enzyme provides effective resistance to beta-lactam antibiotics due to substrate recognition controlled by point mutations. Recently, extended-spectrum and inhibitor-resistant mutants have become a global health problem. Here, the functional dynamics that control substrate recognition in TEM beta-lactamase are investigated ... WebPrevalence of TEM, SHV, and CTX-M Beta-Lactamase genes in the urinary isolates of a tertiary care hospital Prevalence of TEM, SHV, and CTX-M Beta-Lactamase genes in the urinary isolates of a tertiary care hospital Authors Trupti Bajpai 1 , M Pandey 2 , M Varma 3 , G S Bhatambare 4 Affiliations
Beta-Lactamase - an overview ScienceDirect Topics
WebNational Center for Biotechnology Information WebJul 22, 2013 · Second, using either general properties or in silico predictions of mutation effects on stability (14, 16), this model could explain the rate of loss of function of beta-lactamase TEM-1 with the accumulation of mutations. However, these evidences are indirect, based either on sequence analysis or on experimental analysis of mean effects. city of verona wi taxes
Extended-spectrum and inhibitor-resistant TEM-type beta-lactamases ...
WebBeta-lactams are antibiotics that have a beta-lactam ring nucleus. Subclasses include Carbapenems Cephalosporins and cephamycins (cephems) Clavams Monobactams … WebApr 17, 2002 · Widespread use of beta-lactam antibiotics has promoted the evolution of beta-lactamase mutant enzymes that can hydrolyze ever newer classes of these drugs. Among the most pernicious mutants are the inhibitor-resistant TEM beta-lactamases (IRTs), which elude mechanism-based inhibitors, such as clavulanate. Among Gram-negative bacteria, the emergence of resistance to extended-spectrum cephalosporins has been a major concern. It appeared initially in a limited number of bacterial species (E. cloacae, C. freundii, S. marcescens, and P. aeruginosa) that could mutate to hyperproduce their chromosomal class C β-lactamase. A few years later, resistance appeared in bacterial species not naturally producing AmpC enzymes (K. pneumoniae, Salmonella spp., P. mi… city of vestavia hills alabama zoning