WebNov 8, 2024 · Figure 1: The clinker pipeline (a) and visualisation of the burnettramic acid biosynthetic gene cluster (Li et al., ... 70 burnettramic acids (Li et al., 2024) is split over three contigs due to fragmented genome assembly, but is readily 71 visualised by our tool (top-most cluster in Figure 1b). Hovering over a locus displays a grey box with ... WebDec 12, 2024 · Finally, synthetic pyrimidine antimetabolites such as flucytosine interfere with nucleic acid biosynthesis, but resistance via point mutations in the fungal uracil phosphoribosyltransferase or cytosine deaminase enzymes restricts their application to combination therapy [8]. Open in a separate window Figure 1
Discovery and Heterologous Biosynthesis of the Burnettramic Aci…
WebNov 24, 2024 · Background: Nocamycins I and II, produced by the rare actinomycete Saccharothrix syringae, belong to the tetramic acid family natural products. Nocamycins show potent antimicrobial activity and... WebBurnettramic acid A is a fungal metabolite found in A. burnettii which has diverse biological activities. It is active against B. subtilis, S. aureus, C. albicans, and S. cerevisiae (IC50s = 2.3, 5.9, 0.5, and 0.2 µg/ml, respectively). Burnettramic acid A is also cytotoxic to NS-1 murine myeloma cells but not neonatal foreskin fibroblasts ... インスタ 登録 グーグルアカウント
Structural Revision and Absolute Configuration of …
WebMar 1, 2024 · The burnettramic acids are a new class of antibiotics from an Australian fungus Aspergillus burnettii. The rare bolaamphiphilic scaffold consists of β-d-mannose … WebFeb 8, 2024 · Burnettramic acid A (2) was the main constituent of the highly active SPE Fr.8. Its structure was unambiguously confirmed by comparison of its HRMS, NMR and … WebBurnettramic acid A is a fungal metabolite found in A. burnettii which has diverse biological activities. It is active against B. subtilis, S. aureus, C. albicans, and S. cerevisiae (IC50s … padi per vertetim pronesie